Herpes at the corner of the mouth, consider the possibility of having herpes simplex, may be related to low immunity and so on. Herpes at the corners of the mouth should not be punctured, as the blister fluid contains viruses, and puncturing it will cause new infections; in addition, puncturing it may lead to secondary bacterial infections and so on. Herpes simplex blisters contain herpes simplex virus, once punctured, the blisters will flow to other parts of the body, especially the broken parts, then new foci of infection may appear, so that the disease will not be cured. On the other hand, after herpes is punctured, due to the lack of thorough disinfection, etc., there may be secondary bacterial infection in the local area, causing local redness and swelling, and pus exudation with pain, etc. To summarize, herpes simplex should not be punctured. It is a self-limiting disease, and early treatment can shorten the course of the disease. Acyclovir cream can be applied locally, and acyclovir tablets can be taken orally for antiviral treatment. Herpes in the mouth may also be other diseases, it is recommended that the patient consult a doctor in a timely manner, after a clear diagnosis under the guidance of the doctor for treatment, do not puncture, so as not to cause serious adverse consequences.