I often encounter outpatients who are worried: “I heard that after the removal of breast lumps will grow again, so even if I feel the lump is growing, I do not want to do surgery” “After the removal of breast lumps, what to do if the lump grows again?”. . In order to explain this problem, I first told the experience of a doctor in our hospital: she began to find multiple nodules in the breast from the age of 30, our doctors felt one of the hard texture, that can not rule out the possibility of malignant, did the mass removal biopsy, the results were benign. After the surgery, her attending doctor told her that she must have one or two breast examinations every year, and within the next 20 years, she had two more mastectomy biopsies, both of which were benign. 1 year ago, when she was re-examined, she found that the number of new bilateral breast masses had increased in recent years, and the masses had a tendency to grow and change in echogenicity. Both of them were carcinoma in situ, one of them with microinfiltration. The patient was adamant that bilateral mastectomy be performed. Based on the patient’s condition, we chose to perform a total transluminal subcutaneous mastectomy, and postoperative pathology suggested that cancer cells were also detected in one node in the right breast. After the operation, the patient thanked the doctor repeatedly because (1) the nipple areola was preserved with good appearance; (2) the breast cancer was diagnosed and treated appropriately at an early stage, but the doctor said that she should thank herself because she was able to listen to the doctor’s advice and observe the follow-up in the same medical institution for a long time, which ensured the accuracy of the information obtained by the doctor and provided a better basis for the early diagnosis of breast cancer. In fact, some women are more likely to develop breast lumps (tumors) due to their body’s own genes (endogenous factors) and other reasons, and coupled with long-term exposure to exogenous estrogen preparations (exogenous factors), they are at greater risk of growing lumps. Some people have multiple breast masses as soon as they are seen, and some people grow masses in different breast areas at different times, so some people grow masses again after surgery not due to surgical removal. The purpose of surgery is to remove clinically suspected malignant lesions and send the masses for pathological examination to confirm the diagnosis. People who have had breast lumps have a higher risk of breast cancer than normal, so it is important to follow up after surgery (i.e. regular check-ups at breast specialist clinics). If you have avoided long-term exposure to exogenous estrogen and still have lumps after surgery, or if you are at high risk for other breast cancers, you should be followed up more frequently. If a new lump is suspected to be cancerous, it should be removed for biopsy.