Clinically, different treatment methods can be adopted according to the different causes of mediastinal nodules. First, if the patient’s mediastinal nodule is an enlarged lymph node formed due to lung infection, or acute inflammation in the mediastinum. At this time, patients can strengthen anti-infection treatment by intravenous application of antibiotics. After the infection in the body is controlled, the small nodules in the mediastinum can absorb and subside on their own and will not cause serious effects on the human body. If the nodules in the mediastinum are cancerous nodules caused by neoplastic lesions, such as lung malignant tumors and mediastinal malignant tumors. In this case, patients need to improve the enhanced CT examination as soon as possible to clarify the nature of the lesion, and then perform surgery to remove the tumor and clear the lymph nodes as soon as possible. After surgery, combined with local radiotherapy and systemic chemotherapy, the cancer cells in the body should be removed as much as possible to avoid recurrent attacks of mediastinal nodules.