There are more contraindications to intravenous thrombolysis for cerebral infarction, and the common contraindications are as follows: 1, previous history of cerebral hemorrhage, subarachnoid hemorrhage, patients with intracranial aneurysm, arteriovenous malformation and tumor cannot be excluded, and the risk of bleeding from thrombolysis is high; 2, major surgery, gastrointestinal hemorrhage in the last three months, cerebral infarction and cerebral hemorrhage in the last three weeks are not suitable for intravenous thrombolysis; 3, acute gastric perforation occurred in the last two weeks, and the last week The occurrence of large artery perforation that is not easily compressed is not suitable for intravenous thrombolysis; 4. Active traumatic bleeding and recent taking of anticoagulant and antiplatelet drugs resulting in INR over 1.5 is not suitable for intravenous thrombolysis; 5. Taking antiplatelet and anticoagulant drugs within 48h is not suitable for intravenous thrombolysis.