It is possible to have children with nephrotic syndrome after active treatment to control the disease. Women with nephrotic syndrome may also be able to prepare for pregnancy after regular hormone and immunosuppressant therapy. However, the disease may progress throughout pregnancy, the immune system disease is incurable, and pregnancy may lead to abnormal kidney function or even kidney failure. The high level of hormonal stimulation and physiological immune response during pregnancy may cause immune dysfunction in the pregnant woman’s body, inducing another relapse of nephrotic syndrome. Therefore, before and after pregnancy in women with nephrotic syndrome, we should pay attention to the monitoring of urine routine, urine protein quantification and renal function, timely treatment when abnormalities occur, and termination of pregnancy if necessary.