Cutaneous mucocutaneous lymph node syndrome, also known as Kawasaki disease, is a connective tissue disease with metaplastic systemic small vessel vasculitis as the main pathological change. The main manifestations are acute fever, skin and mucosal lesions and lymph node enlargement. It is common in infants and young children. The incidence of the disease has increased significantly in recent years in China. Etiology: The etiology is unclear and may be related to infection. Immune response and environmental pollution, drugs, chemical agents and other related. The lesions can involve arteries, veins and capillaries, and can invade multiple systems throughout the body, resulting in a variety of clinical manifestations, the most serious being coronary artery lesions, which are often the main cause of death. Clinical manifestations: the duration of the disease is mostly 6 to 8 weeks, and can last for months to years when there are cardiovascular symptoms. 1, the main manifestations: ① fever, in the form of fever or flaccid fever, lasting 1 to 2 weeks. Skin and mucous membrane manifestations: polymorphic urticaria-like, erythematous or scarlet fever-like rash on the trunk, without blisters or nodules. The ends of the extremities show solid swelling at the beginning of the disease and membranous peeling of the fingertips during the recovery period, which is characteristic of the disease. The conjunctiva of both eyes is congested without purulent discharge and tearing, the lips are dry and flushed, chapped, with a prune tongue, and the mucous membranes of the mouth and pharynx are diffusely red without ulceration or pseudomembrane formation. 2. Non-purulent enlargement of cervical lymph nodes: about half of the patients may have enlarged cervical lymph nodes unilaterally or bilaterally, with transient lymph node enlargement, which is most obvious on the fifth day after the onset of the disease, with localized pressure pain, but no signs of purulence are seen, and the enlarged The swollen lymph nodes have endothelial and mesothelial inflammation, and the perivascular connective tissue is highly edematous with obvious inflammatory cell infiltration, and rickettsial-like particles are often found in the phagocytic plasma around the vessels. 3, cardiovascular signs and symptoms: rare, but very important. The manifestations are cardiac murmur arrhythmia, heart enlargement, and heart failure. Those with coronary artery disease may show myocardial ischemia or even myocardial infarction. 4, other accompanying symptoms: diarrhea, vomiting, abdominal pain may occur. Or pus urine, hematuria, etc. Laboratory tests: increased blood leukocytes, increased neutrophils, increased sedimentation, increased C-reactive protein, increased immunoglobulins, increased transaminases in some cases, electrocardiogram and echocardiogram changes in those with heart damage. Treatment: 1. glucocorticoids 2. aspirin 3. intravenous gammaglobulin 4. other treatments: symptomatic past treatment Symptomatic and supportive therapies are given according to the resected condition, such as supplemental fluids to protect the liver authority to control heart failure and correct arrhythmias, etc. Thrombolytic therapy should be performed in time for myocardial infarction Severe coronary artery lesions require coronary artery bypass grafting Prognosis: The disease is self-limiting and most have a good prognosis