The right big toe numbness is dangerous, common in the following diseases: 1, lumbar disc herniation patients due to lumbar disc compression of the right sciatic nerve, will lead to the patient appeared in the right big toe numbness symptoms. If further progress will cause the patient’s right lower limb activity pain, right lower limb weakness, serious condition will also appear right lower limb inactivity, the need for surgical treatment; 2, diabetes mellitus patients if long-term blood sugar control is poor, resulting in the sensory nerves of the right lower limb is affected, diabetic peripheral neurosis, the right big toe numbness will occur. Further progress of the right lower extremity will appear pinprick-like, ants gnawing-like pain, and even the right lower extremity skin, muscle and other soft tissue necrosis, ulceration, gangrene and other symptoms of diabetic foot, and finally lead to amputation.