Chromosomal inversions between arms can affect fetuses with chromosomal or developmental structural abnormalities. When non-invasive prenatal testing or prenatal diagnosis during pregnancy suggests chromosomal inversions (e.g., chromosome 7 or 9, Y chromosome, etc.), it may result in a combination of chromosomal anomalies or congenital structural anomalies, such as congenital heart disease, in the fetus. Long-term effects include infertility or recurrent miscarriages during the reproductive period in female fetuses, and infertility in the female partner in male fetuses. For those at high risk of chromosomal structural abnormalities detected by screening or couples who give birth to babies with severe congenital defects, timely prenatal counseling and prenatal diagnosis are required after pregnancy to rule out the risk of chromosomal disorders in the fetus. For couples with a history of recurrent adverse pregnancies, third-generation in vitro fertilization-embryo transfer (IVF-ET) can be performed under medical supervision to conceive, if necessary.