Gastric ulcer 2cm belongs to huge ulcer and has the possibility of malignancy, which needs to complete pathological examination first. After determining that it is not gastric cancer, it can be treated with drugs to inhibit gastric acid secretion, drugs to protect gastric mucosa and drugs to eradicate Helicobacter pylori. 1. Drugs to inhibit gastric acid secretion: commonly used drugs include proton pump inhibitors and H2 receptor antagonists, such as omeprazole and cimetidine, which can inhibit the secretion of gastric acid and promote the healing of ulcer. Common adverse reactions include abdominal pain, bloating, constipation, nausea and so on. 2. Drugs to protect gastric mucosa: commonly used drugs bismuth and antacids. Commonly used bismuth agent is bismuth potassium citrate, which can be coated on the surface of the ulcer, blocking the invasive damage of gastric acid and pepsin on the mucosa. Nausea and constipation may occur after taking it. In addition, taking this type will color the tongue and feces black. 3. Eradication of Helicobacter pylori drug treatment: Helicobacter pylori infection is the most important cause of peptic ulcer. For patients with H. pylori infection, H. pylori eradication treatment is needed. The current treatment program is two antibiotics, a proton pump inhibitor, a bismuth agent. Treatment of gastric ulcer needs to go to a regular hospital, under the treatment of a professional doctor for a full course of treatment, regular review after treatment, should avoid self-treatment, so as not to delay the condition. Drugs need to be used under the guidance of a professional physician, not self-medication.