Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly and its development is associated with anthropological factors (race, gender), dietary factors (vitamin deficiency, excessive consumption of fatty foods, large fish and meat, and alcohol abuse), and environmental factors (smoking, prolonged exposure to the sun). Common risk factors have been reported for AMD and cardiovascular disease, such as clinical conditions such as hypertension, myocardial infarction, stroke, hyperlipidemia; subclinical lesions such as carotid plaque and intima-media hyperthrombosis, magnetic resonance showing cerebral white matter lesions; and inflammatory (C-reactive protein) and genetic factors (apolipoprotein e gene, polymorphic complement factor H). However, there are no studies on the correlation between the severity of coronary artery disease (CAD) quantified by coronary angiography and the prevalence of AMD. Sarah B Wang et al from the Westminster Institute in Australia conducted an observational study and found that the prevalence of early age-related macular degeneration was independently associated with the severity of coronary artery disease, and the results were recently published in Br J Ophthalmol. A total of 1680 patients with potential CAD diagnosed by coronary angiography at tertiary referral hospitals were included in this study, and their severity and extent of lesions were assessed by a three-level scoring system: involvement of vessels and segments score, Gensini score, and extent of involvement score. The final 1545 patients provided information about AMD, as well as complete CAD severity and extent score data. The study showed that the incidence of AMD was 5.8% and 1.4% in early and late stages, respectively. After multivariate adjustment, those with >50% stenosis in any segment of the coronary artery (according to the involved segment score) were nearly two times more likely to have early AMD than those with <50% stenosis. Patients with stenosis in all three major coronary arteries were more than two times more likely to have early AMD than those without any coronary stenosis, and the prevalence of early AMD was nearly two times higher in the highest Gensini score group than in the lowest group. The study showed that the severity of coronary stenosis was independently correlated with early AMD and was not related to the extent of coronary stenosis, whereas CAD was not significantly correlated with late AMD. Taken together, the significant correlation between CAD and early AMD suggests the need to screen patients with coronary artery disease to prevent and treat early age-related macular degeneration, a finding that has important clinical implications.