Although the mainstream orthodontic techniques currently used both nationally and internationally generally follow the principle of gentle and light forces. Usually, under the appropriate orthodontic force, no significant or unbearable pain occurs in orthodontic teeth, but it is not senseless. Most patients may experience mild pain at the beginning of the orthodontic treatment or after the force of the archwire, or may experience soreness and swelling, and may not be able to bite into hard foods, but this usually resolves within a few days. There is a large individual variability in whether orthodontic forces produce significant pain, and generally pediatric patients have a better tolerance of pain response than adult patients under the same orthodontic forces. Most patients experience more pronounced sensations within the first 3 to 4 weeks of treatment, after which they gradually disappear on their own. Inappropriate excessive orthodontic forces may induce periodontal tissue damage and cause orthodontic tooth pain. In addition, during the process of tooth movement, because a new occlusal balance contact relationship has not yet been established, occlusal interference between upper and lower teeth may occur, resulting in traumatic contact between the cusps, which may also cause pain in traumatized teeth. If this happens, the occlusal interference should be eliminated in time and the pain will subside. There are very few cases of orthodontic pain that require pain relievers.