The importance of cranial bone is self-evident, however, many people in life have cranial defects for one reason or another, which seriously affects the aesthetics and is a great harm to their health. Cranial defect is a big problem, and patients must pay attention to it and undergo cranial repair surgery in time. When it comes to cranial repair surgery, the key point is the choice of repair material, only good material repair effect will be better. At present, the titanium mesh material is widely used in medicine, but there are some defects of titanium mesh material that have the occurrence of rejection reaction. The disadvantages of titanium mesh skull repair: 1, after the skull titanium mesh repair, must pay attention to avoid infection problems, to avoid another collision injury, because the hardness of titanium mesh material is not very strong, in some strong collision and impact will lead to deformation. 2, after the surgery, can not be exposed to the sun, otherwise it will lead to a significant burning sensation of the patient’s scalp, affecting the results. In addition, it is not advisable to stay in too cold environment. 3, titanium mesh repair skull after, must not do some more strenuous sports, such as bungee jumping and so on. 4, titanium mesh is a metallic material, after the surgery can not do CT MRI, because it will lead to artifacts, which will affect the diagnostic results. Obviously, there are still many contraindications to using titanium mesh material for skull repair surgery, and there are also many defects. Therefore, it is no longer recommended to use titanium mesh for skull repair surgery. There is also a new type of material that can be used, which is peek material, the characteristics of this material is comparable to the human skull, the postoperative effect is quite good, and do not have to worry about any adverse reactions and sequelae. It is reported that PEEK cranial bone repair plastic surgery, can achieve anatomical integrity, functional perfection, aesthetic appearance of the organic unity, significant results. With 3D printing, comparable to autologous cranial bone, it is the preferred cranial bone repair material for patients.