The HFMD vaccine is administered for at least two years, and if a child has received the HFMD vaccine, there is no need to revaccinate within two years of vaccination. This is because it has been clinically proven that two years after vaccination, the protective antibodies in the child’s body are still at a particularly high level and can effectively prevent severe HFMD in children. The HFMD vaccine currently targets EV71 enterovirus infection, which can cause severe HFMD in children, and prevents serious complications such as encephalitis and neurogenic pulmonary edema in children. In summary, the HFMD vaccine can be administered for more than two years.