Indications for plasma transfusion include: coagulation factor deficiency, liver disease, coagulation dysfunction caused by massive infusion, bleeding due to overdose of oral anticoagulants, antithrombin deficiency, thrombotic thrombocytopenic purpura, plasma exchange, and extensive burns. At present, the main plasma products commonly used in clinical practice are fresh frozen plasma (FFP) and ordinary frozen plasma (FP). 1. Indications of fresh frozen plasma (1) Deficiency of individual coagulation factors: supplementation with fresh or frozen plasma. (2) Acquired coagulation factor deficiency in patients with liver disease: generalized reduction of coagulation factors due to liver disease. (3) Coagulation disorders caused by massive infusion: mainly caused by plasma dilution, corrected by plasma infusion. (4) Bleeding due to overdose of oral anticoagulants: plasma supplementation after discontinuation of the drug brought the bleeding under control. (5) Anticoagulant deficiency: risk of thrombosis, replaced with plasma with better results. (6) Thrombotic thrombocytopenic purpura: plasma infusion is also an effective treatment. (7) Plasma replacement: a certain amount of plasma is needed for patients with large replacement volume or with coagulation factor deficiency. (8) Large burns: plasma is a more ideal colloid solution, and can also supplement immunoglobulin and other components. 2. Frozen plasma (FP) infusion: FP contains all the stable coagulation factors, but lack of unstable coagulation factor V. In addition to not being able to be used for coagulation factors V and VII supplemental therapy, other items with FFP. Adverse effects of plasma infusion include rash, diarrhea, fever, etc. Plasma infusion therapy is prohibited for those with incompatible blood groups. If plasma transfusion is needed, it is recommended to be carried out under the guidance of a doctor to avoid adverse effects.