Another culprit of ED – metabolic syndrome Company account manager Zhang is 32 years old, he was not fat, in recent years, because of more entertainment, almost every day drinking, overeating, never exercise. With the growth of income, abdominal circumference also increases every day, watching people like a balloon “expansion”. In recent days, the daughter-in-law and he began to quarrel, not for the sake of other, or because of the life of the couple that thing. The daughter-in-law cried to her mother-in-law, since Zhang socializing more, on that aspect began not interested, occasionally to come once more and more unable to do so, the last half months simply completely strike. It is said that men become bad when they have money, could he also spend a lot of time outside, home can not pay the “public food”? In both parents “forced”, Zhang came to the hospital, according to the male doctor’s consultation and examination, determined that Zhang suffered from erectile dysfunction (ED), hyperlipidemia and hypertension, and the cause may be “metabolic syndrome”. This, Zhang puzzled, what is the relationship between metabolic syndrome and ED? First of all, let’s understand what is metabolic syndrome? The metabolic syndrome (metabolic syndrome, MS) is a pathological state, manifested by the abnormal aggregation of a variety of metabolic components, the body often occurs in complex metabolic disorders. MS can cause widespread endothelial cell damage in the arteries, which can lead to cardiovascular disease, and therefore become a risk factor for diabetes, cardiovascular disease. The definition of MS has been controversial in the international academic community, and in 2004, the International Diabetes Federation (IDF) developed a global consensus on MS. The diagnostic criteria are: i. “Central obesity” (waist circumference ≥90CM for Chinese men and ≥80CM for women) ii. any two of the following four indicators: (1) elevated triglyceride (TG) levels: >150mg/dl (1.7mmol/l), or have received appropriate treatment; (2) (2) Decreased high-density lipoprotein-cholesterol (HDL-C) levels: <40 mg/dl (0.9 mmol/l) in men and <50 mg/dl (1.1 mmol/l) in women, or treated accordingly; (3) Elevated blood pressure: systolic blood pressure ≥130 or diastolic blood pressure ≥85 mmHg, or treated accordingly or previously diagnosed hypertension; (4) Elevated fasting blood glucose (FPG): ≥100 mg/dl (1.7 mmol/l), or treated accordingly (4) elevated FPG: ≥100 mg/dl (5.6 mmol/l), or previously diagnosed or treated for type 2 diabetes. So, what is the association between MS and ED? It was found that MS patients are more prone to endothelial dysfunction, they are more likely to have reduced expression and activation of endothelial NO synthase, and consequently the arterial blood circulation in the penile corpus cavernosum tissue is more likely to be altered. Both oxidative stress and tissue inflammation play an important role in this process, and when accompanied by these reactions, the severity of ED increases. On the other hand, it has been found that MS patients are often accompanied by hypogonadism, which is also associated with low levels of testosterone and manifests itself in a range of symptoms including decreased libido, reduced frequency of intercourse and mental depression. In addition, numerous studies have been conducted on the relationship between ED, MS and cardiovascular disease, respectively, and found that the factors that constitute MS are also risk factors for ED. How to prevent and treat the ED caused by MS? For the prevention and treatment of MS, the first consideration should be to reduce the various risk factors for MS, including effective weight loss, reduction of insulin resistance, good control of blood sugar, improve lipid metabolism disorders, control blood pressure and other "three highs". Lifestyle changes, including changing diet and increasing exercise, have become the main means of MS treatment. In recent years, treatment for endothelial impairment has become a hot topic in MS-ED treatment. Some studies have shown that long-term treatment with small doses of PDE5 inhibitors (commonly known as Viagra, commonly treated with cialis 5mg daily orally) can effectively improve endothelial function, which can effectively help treat ED. After listening to the doctor's explanation, Xiao Zhang finally understood his problem and expressed his willingness to undergo relevant treatment according to the doctor's recommendations. And Zhang's lover also expressed willingness to cooperate with her husband's treatment, and will be supervised. After more than half a year of treatment, Zhang has successfully lost weight, erectile capacity is naturally restored as before.