There is no clear clinical statistics on the success rate of IOL secondary replacement, but in some special cases, IOLs can be replaced twice, but the exact prognosis is related to the patient’s condition. IOL implantation is mostly used in cataract surgery, which has a wide range of surgical scope, including people with clouding lens, visual acuity less than 0.3, dislocated or semi-dislocated lens, high myopia combined with cataract, congenital cataract, and cataract combined with glaucoma, and other conditions. The success rate of the first IOL implantation is high, while the second IOL replacement surgery will bear a higher risk. Therefore, it is generally not recommended to remove the IOL unless there is a special reason for a second IOL replacement, and the success rate of the surgery is related to the patient’s condition. If a patient’s original IOL is inappropriate, inappropriate or out of position, the original IOL can be surgically removed and a new IOL can be implanted. It is recommended that post IOL implantation patients follow the doctor’s instructions, have regular checkups, and seek prompt medical attention when discomfort occurs.