Nifedipine controlled-release tablets combined with indapamide are commonly used clinically in the treatment of hypertension with certain effects, but the applicability should be determined after diagnosis by a doctor. Nifedipine controlled-release tablets are calcium antagonists, which can inhibit calcium ion-mediated vasoconstriction and then dilate blood vessels, thus lowering the patient’s blood pressure. Indapamide is a diuretic with diuretic effect, which can reduce blood volume through diuresis, thus lowering blood pressure. Nifedipine controlled-release tablets and indapamide can produce antihypertensive effect, and the mechanism of action of the two are different, the joint use of drugs can play a synergistic effect so as to better reduce blood pressure, can be clinically used together. And nifedipine may cause lower limb edema and other conditions, can be indapamide’s diuretic effect to alleviate or eliminate. Combined use of the two can better reduce the patient’s blood pressure, but whether to use the drug should be in the doctor to diagnose the patient’s condition before considering the use of drugs, do not blindly self-medication.