Diet and exercise to lose weight for many obese patients is possible to reduce weight, but almost always will invariably rebound, so why diet and exercise can not lose weight successfully? When you exercise after work, etc., the body needs calories but can not get, it will choose to slow down the metabolism in order to reduce the consumption of energy, rather than through a complex biochemical reaction, the body fat into energy. So eating less will only be our body to reduce consumption, and not help us reduce fat. At the same time, dieting for a long time, the body thinks that the famine is coming, will find ways to accumulate fat, muscle loss, the basal metabolic rate will slow down, so once the diet can not be maintained, even if it is just eating the same food as before, the body will think it is eating too much, the extra calories will be converted into fat storage, the result is that you are fatter than before. After a person has recovered from a famine, his body will find ways to store more fat in case of the next famine. The energy burned by exercise is often offset by the subsequent increase in calorie intake. Each person’s metabolism has a tuning point, and those with fast metabolisms have a lower tuning point than those with slower heart sink metabolisms. This point does not depend on the amount of calories consumed or consumed. Weight gain is the point at which the adjustment point rises, when the hormones of our metabolism change and the adjustment point of our weight rises. Therefore, the lack of success in weight loss is not only due to the lack of willpower of the person, he has physiological reasons, so to reduce the adjustment point and lose weight, it is important to eat the right food and choose the right exercise method. When glucose in the blood rises, the secretion of insulin increases and is used to absorb glucose. Too much glucose in the cells is converted into fat, and for obese patients, who eat too much, glucose in the blood rises quickly and the pancreas releases large amounts of insulin, leading to hyperinsulinemia. With too much insulin, the cells do not burn fat. With high insulin and more blood sugar, the effect of leptin is affected, and even though there is already a lot of fat, the person’s appetite is not affected and there is no desire to exercise, so the weight set point is raised. A large number of follow-up studies have shown that for patients with severe obesity either a low-calorie diet or diet control plus exercise will reduce weight, but by 5 years later almost always regain weight, and as long as they lose weight once, rebound will occur, resulting in more and more weight loss. Diet and exercise are ineffective for weight loss in patients with severe obesity. For patients with severe obesity, weight loss after surgery will reduce the patient’s caloric adjustment point, making the diet control easier and the hyperinsulinemia relieved. Thus, the long-term effect of weight control can be achieved.