Taking nifurtimox tablets can lead to yellow urine. Nifurtimox belongs to the furan class of antibiotics and can cause yellow urine staining when taken orally. Taking sulfonamide antibiotics or vitamin B can lead to yellow urine staining, which is not an abnormal phenomenon, but a manifestation of drug staining. After stopping the drug intake, the urine color can return to normal, so for patients taking nifurtimox tablets, if the course of treatment is over or the symptoms are relieved, stop the drug as soon as possible. During the period of taking the drug, you need to drink more water appropriately, ensure that the amount of water is about 1500ml, and moderate alkalinization of urine. You can also take one oral sodium bicarbonate tablet three times a day and discontinue it together with nifurtimox tablets. If you do not drink water for a long time, it can not only cause yellow color of urine, but even form drug crystals appear. It is necessary to drink more water appropriately, wait for the end of the course of treatment, and stop the drug in time.