If the patient is currently taking nifedipine controlled-release tablets and the blood pressure still does not come down, in this case, it is recommended that the patient can use a combination of antihypertensive agents to further lower the patient’s blood pressure. For example, patients are advised to choose angiotensin-converting enzyme inhibitors or angiotensin di-receptor antagonists, whose representative drugs are perindopril, benazepril, telmisartan, and colesartan, etc. Choose any one of these types of drugs and apply them in combination with nifedipine controlled-release tablets to help lower the patient’s blood pressure better. If taking such a program as above, still can not bring the blood pressure control up to the standard, this time also can be combined with hydrochlorothiazide tablets, a diuretic, relatively speaking, will play a better efficacy, if the addition of hydrochlorothiazide tablets is still less effective, can also be combined with beta-blockers, the representative drugs are metoprolol, bisoprolol, etc. If the application of four types of antihypertensive drugs, blood pressure still can not be controlled up to the standard, this time must pay attention to find, what is the cause of the emergence of this refractory hypertension, such as whether the patient did not combine low salt, low-fat diet, did not quit smoking, quit drinking, did not exercise to lose weight, in addition, there are some patients are often mental stress, always tired and stay up late.