Vaginal opening pain, mucosal injury should be in a clear cause and then targeted treatment, the disease is related to mycotic vaginitis can be treated with clotrimazole, trichomonas vaginitis can be intervened with metronidazole drugs. 1. Mycotic vaginitis: mycotic vaginitis is a disease caused by women due to sexual impurity and other reasons, under the stimulation of inflammatory factors will cause the body to have a series of adverse reactions, resulting in pain. Generally can be used under the guidance of the doctor clotrimazole, miconazole nitrate drugs, this type of drug may make the body dizziness, nausea and other discomforts, allergic to the drug components or severe liver dysfunction is prohibited. 2. Trichomonas vaginitis: vaginal pain, mucous membrane damage may also be due to trichomonas vaginitis, the disease will make the body accompanied by frequent urination, painful urination symptoms. Metronidazole can be used to intervene in the drug, the drug may make the body loss of appetite, vomiting and other adverse reactions, allergic to drug components or severe liver dysfunction is prohibited. Vaginal opening pain, mucous membrane damage, it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, give targeted treatment or treatment, do not use drugs privately.