Aggressive diffuse large b-cell lymphoma stage II usually requires the use of drug therapy and chemotherapy under the guidance of doctors. 1. Drug therapy: patients can use targeted drugs such as rituximab and chaste astragali fuzheng granules under the guidance of doctors to carry out treatment, which can increase the body’s immunity and play the role of anti-tumor. 2. Chemotherapy: the usual chemotherapy program is CHOP program (cyclophosphamide, doxorubicin, vincristine, prednisone), which has certain curative effect for patients with aggressive diffuse large b-cell lymphoma stage II. Some patients can also be treated with radiotherapy, etc. It is recommended to seek timely medical treatment for relevant examinations, and according to the specific situation, under the guidance of the doctor, carry out symptomatic treatment.