What are the uses of Hepatitis B GeneChip GeneChip technology is a new technology developed in recent years, the principle of which is to fix hundreds or even thousands of cDNA or oligonucleotide fragments on nylon membranes or slides, and use nucleic acid molecular hybridization to detect the expression levels and changes of genes under physiological or pathological conditions. Since Fodor proposed the concept of DNA microarrays in 1991, the technology has shown great potential for development in various fields of medicine. DNA microarray technology provides a rapid, sensitive and efficient method for the diagnosis of hepatitis virus, especially for the subtypes of hepatitis B virus, mutant and drug-resistant strains, which can be diagnosed by a single microarray at the same time. Since hepatitis B virus has a strong mutation ability, and the spectrum of diseases manifested after infection is very wide, the application of antiviral drugs and the result of natural immune selection often cause it to undergo directed or undirected mutation, which brings a lot of difficulties for clinical treatment and diagnosis. The Hepatitis B gene chip testing technology introduced by us can simultaneously detect the mutations of 6 loci almost covering more than 90% of the mutation types of Hepatitis B, which can fully meet the needs of clinical treatment and diagnosis. Then who needs to do hepatitis B gene test? Before choosing antiviral drugs for chronic hepatitis B patients, they can do the hepatitis B genetic test to find out whether there are drug-resistant variants in their bodies and to avoid detours in antiviral treatment, wasting time and spending more money. In the course of antiviral treatment, if the HBV-DNA turns negative and then turns positive again or decreases and then rebounds, it is very likely that a mutant strain has appeared in the course of antiviral treatment, which can be found and adjusted in the antiviral program in time through the test. The sudden change of major triple positive to minor triple positive often does not mean that the virus does not replicate, but may be caused by the wild strain of the C region of the mutation, to avoid host recognition and achieve the purpose of rapid replication, at this time the condition is often changed, genetic testing can help to understand the mutation of the virus, and to find a way to solve the problem. For those with abnormal serum hepatitis B five indicators, such as three antibodies, four-positive, two-positive, it is difficult to determine whether the virus is replicating or infectious only from the five indicators, and the hepatitis B gene chip can detect a variety of mutant strains and wild strains, and guide the patient to determine whether antiviral treatment is necessary. The sudden deterioration of disease, such as long-term hepatitis B virus carriers with no clinical manifestations, and the recent sudden emergence of symptoms and aggravation of disease, is often due to the mutation of hepatitis B virus, the body from the original state of immune tolerance to the state of immune attack, and begin to attack the new mutated virus, which then causes extensive necrosis of liver cells, resulting in severe hepatitis, if the mutated strain is detected at an early stage, and the choice of drugs targeting mutated strains will stop the replication of mutated strains, and thus prevent the immune system from being affected by the virus. If the mutated strain is detected at an early stage, selecting a drug that targets the mutated strain will stop the replication of the mutated strain, thereby preventing immune damage and avoiding the development of severe hepatitis. Infected people in high-risk groups, if there are hepatitis B patients with liver cancer in their families, their children will have high chances of developing liver cancer after suffering from hepatitis B. This is mainly due to the family genes and the type of infected hepatitis B virus, and early identification of hepatitis B virus mutant strains is often helpful in early indication of the likelihood of the infected people suffering from liver cancer. Therefore, Hepatitis B Virus Gene Chip is very versatile and very suitable for the requirements of the majority of Hepatitis B patients, and it has found a new solution for the diagnosis and treatment of Hepatitis B.