1.Case sharing The patient was 26 years old, married and childless, with irregular menstruation, and underwent laparoscopic surgery for a pelvic mass. During the operation, the left ovarian mass was 5cm in size, with a smooth surface and no adhesion to the surrounding area; it was removed laparoscopically and did not rupture. Postoperative pathology was diagnosed as ovarian amphotericoblastoma in both hospitals. Postoperative monitoring of estrogen and androgen were both abnormally elevated. Is there any further treatment needed? 2. Literature review Ovarian amphoblastoma is very rare and is usually a small benign tumor with both supportive-mesenchymal and granulosa cell differentiation, which is diagnosed only when the percentage of secondary components (supportive-mesenchymal or granulosa cells) in the tumor reaches at least 10%. The age range of patients at the time of diagnosis is 16-60 years (mean 30 years). The pathogenesis of the disease is unclear, and the most acceptable theory may be that the mesoderm of the genitourinary crest produces endocrinally active gonadal tissues (e.g., granulosa cells, supportive cells, follicular membranous cells, etc.) from which amphibroblastomas originate. These rare mixed tumors secrete androgens (and, less commonly, estrogens) and may cause masculinization or signs of increased estrogen production, such as breast tenderness, postmenopausal bleeding, menstrual abnormalities, or precocious puberty in children. Due to the rarity of ovarian amphotericoblastoma, it has not yet been included in the WHO classification of tumors of the female reproductive organs. Microscopically, granulosa cells are arranged as microfollicles in rounded islet-like structures with Call-Exner vesicles visible within. Supporting-mesenchymal cells are intermingled. The granulosa cell component of ovarian amphotericoblastomas is predominantly adult-type granulosa cell tumors, overexpressing 14-3-3σ protein (an anti-apoptotic chaperone protein). Both adult and juvenile types are positively expressed for vimentin and inhibin, and also express CD99, calretinin. Although granulosa cell tumors have been associated with endometrial cancer, they have not been found in hermaphroditic cytomas and may be related to the young age of the patients and often early diagnosis. Amphotericoblastoma can be effectively treated by unilateral salpingo-oophorectomy, and only one case of recurrence has been reported in the literature, which, after re-excision of the mass, was recurrence-free as of the time of the literature report. Only one case of clinical malignancy has been reported.