The pathological diagnosis of lymphoma, like other histological diagnoses, can also lead to missed diagnosis or misdiagnosis. This occurs mainly in pathological reports of punctured lymphoma, or in pathology departments that lack diagnostic tools, where the punctured specimen does not penetrate to the typical site, or where the surgically removed lymph nodes are next to the main body of the tumor, which may lead to missed diagnosis. Atypical lymphoma lesions can be diagnosed with immunohistochemistry and molecular testing programs to confirm the diagnosis. If these programs are not available, inexperienced pathologists may miss the diagnosis or misdiagnose the disease. Some inflammatory lesions can present very similarly to lymphoma and have a high rate of misdiagnosis, such as cervical lymphoid hyperplastic lesions and childhood infectious mononuclear cell hyperplasia. These are essentially inflammatory lesions, but the morphology is very similar to that of diffuse large B. If the testing program is not done adequately and the pathologist does not have sufficient clinical experience, it can easily lead to misdiagnosis. In conclusion, lymphoma is very difficult to diagnose and easily missed or misdiagnosed. Rich clinical experience and abundant testing programs carried out can help reduce misdiagnosis or missed diagnosis of lymphoma.