Waking up at night with itching should be considered for the following diseases: first, anal pruritus, where the original itching is aggravated by parasympathetic excitation at night, which can lead to waking up with itching during sleep. Secondly, some other diseases in the anus, including hemorrhoids, anal fissures, anal papillae hypertrophy, and sinusitis, lead to overflow at the anal opening and increased itching at night. Again, another possibility is parasitic diseases, the most common being pinworm disease. Since pinworms crawl outside the anus at night and lay eggs in the perianal area, the itching will be more intense at night, and it is also easy to wake up at night with itching. Finally, no matter what the cause is, it is necessary to go to the hospital for a comprehensive examination to clarify the cause of itching and to carry out symptomatic treatment. In daily life, we should pay attention to local cleanliness and hygiene of the anus, try to avoid spicy and stimulating foods, including coffee and alcohol, as well as avoid smoking.