Redness and swelling of the cheeks without pain or itching may be caused by angioneurotic edema, systemic lupus erythematosus, mitral stenosis and other diseases, and the patient should consult a doctor in time to clarify the cause of the disease. 1. Angioneurotic edema: a kind of limited edema that occurs in subcutaneous loose tissues or mucous membranes, patients may show redness and swelling of cheeks without pain or itching, and there is no indentation when pressed by hand, which can be treated with loratadine, cetirizine and so on. 2. Systemic lupus erythematosus (SLE): If the swelling and redness of the cheeks are butterfly-shaped, and the patient also has mucous membrane ulcers, arthralgia and other symptoms, then it should be considered to be caused by SLE, and it can be treated with methotrexate, ibuprofen and so on. 3. Mitral valve stenosis: the obstruction of blood flow caused by the restriction of mitral valve opening, patients will have dyspnea, hemoptysis, facial redness and swelling but painless, loss of appetite and other symptoms, can be treated by surgery. It is suggested that patients should go to the hospital in time, clarify the cause of the disease and then follow the doctor’s instructions for treatment, the above drugs and operations should be carried out under the guidance of the doctor.