The causes of sore throat are many, may be related to acute pharyngitis, pharyngeal mucosal ulcers, acute tonsillitis and other conditions, there is no “what is the best medicine to say”, it is recommended to the hospital ENT consultation, according to the type of disease, follow the doctor’s instructions to choose reasonable treatment. 1. Acute pharyngitis: pharyngitis is often associated with viral or bacterial infections, the need to use compound chlorhexidine gargle, compound borax solution and other medications for symptomatic treatment; such as the combination of bacterial infections can be used to control the infection of antibiotics, such as penicillin V potassium tablets, amoxicillin capsules, etc., with a history of allergic to the drug patients are prohibited. If the combination of viral infection, can apply oseltamivir, four seasons antiviral drugs. 2. Pharyngeal mucosal ulcers: patients with pharyngeal mucosal ulcers will have obvious pain. Throat sword spray or watermelon cream spray can be applied; those with severe pain can take oral ibuprofen extended-release capsules for pain relief or topical application of lidocaine gel spray and other drugs to relieve pain. 3. Acute tonsillitis: Inflammation of the tonsils can cause throat pain. Cefuroxime, cefixime and other antibiotics can be used for anti-infection treatment, control of inflammation, patients with a history of drug allergy is prohibited. It is recommended that patients with sore throats go to the ENT department of the hospital as soon as possible, and strictly follow the doctor’s instructions to use medication, do not abuse the drug on your own, so as not to delay the condition or cause other serious adverse consequences.