Peptic ulcer disease is a common and frequent disease of the digestive system, with the stomach and duodenum being the most common. The incidence and complication rates of peptic ulcer disease have improved considerably over the past 30 years with the use of potent acid suppressants and the eradication of Helicobacter pylori therapy, but it is still one of the most common digestive disorders. Especially in recent years with the increasingly widespread use of non-steroidal anti-inflammatory drugs (NSAIDS) and low-dose aspirin, we recognize that peptic ulcer remains an important clinical problem. Tests such as the urease test or nucleotide labeled C breath are encouraged routinely for peptic ulcer disease.” There are numerous diagnostic methods for H. pylori infection, each with its own advantages and disadvantages. The urease test is easy to perform, but active bleeding from peptic ulcer, severe atrophic gastritis, and recent application of antibiotics or proton pump inhibitors (PPIs) may result in a false-negative urease dependent test. More reliable results may be obtained by testing at different times, using multiple methods, or using non-uremic enzyme-dependent tests. Among other testing methods, histopathological examination suggesting the presence of active inflammation is highly suggestive of the presence of H. pylori infection; in patients with active ulcers, excluding NSAID factors, the probability of H. pylori infection is more than 95%, and in these cases, a negative H. pylori test should be highly suspicious of the possibility of false negatives. Review after eradication, usually need to stop PPI after one month to check, can do breath test. The treatment of choice for peptic ulcer disease combined with active bleeding is endoscopic hemostasis. For the timing of endoscopy, US guidelines recommend that in patients with higher clinical features (e.g., tachycardia, hypotension, vomiting blood, etc.), endoscopy within 12 hours may improve patient prognosis. Our guidelines for the diagnosis and management of acute non-variceal upper gastrointestinal bleeding recommend 24 to 48 hours. Where there is active bleeding, exposure of blood vessels at the base of the ulcer or adherence of red or black blood crusts (i.e. Forrest grading I and II), appropriate hemostatic treatment should be performed endoscopically. Pharmacological treatment with a course of 6-8 weeks. A quadruple therapy consisting of bismuth + PPI + 2 antibacterial drugs is recommended as the first-line regimen. Among them, the 4 component regimens of antibiotics include: amoxicillin + clarithromycin; amoxicillin + levofloxacin; amoxicillin + furazolidone; tetracycline + metronidazole or furazolidone. The recommended antibacterial drug composition regimen for penicillin allergy is: clarithromycin + levofloxacin; clarithromycin + furazolidone; tetracycline + metronidazole or furazolidone; clarithromycin + metronidazole. The duration of H. pylori eradication is extended to 10 to 14 days.