Cold sweat from cold hands and feet can be interpreted as yang deficiency from the perspective of Traditional Chinese Medicine (TCM), and can be improved by using Si Yi Tang. Four Reversals Tang consists of Radix Psoraleae, Radix et Rhizoma Glycyrrhizae, and Radix et Rhizoma Glycyrrhizae, and has the effect of warming the middle Jiao, dispelling cold, and restoring Yang (by warming the Yang energy, it saves fainting and unconsciousness, etc.). The combination of the pungent and hot dry ginger with the Radix et Rhizoma Polygoni Multiflori is able to replenish the yang of the spleen and kidney, warming the middle and dispersing the cold (dispersing the cold with medicine that warms the spleen and stomach). The roasted licorice in the formula of Si Yi Tang not only tonifies spleen yang and benefits kidney yang, but also harmonizes the medicinal properties of the two herbs. In this way, the acquired and the innate help each other, assisting Yang Qi to rise and dispel the cold in the body. The adverse effects and contraindications of Si Yi Tang are not clear, and it needs to be used under the guidance of a physician. For patients with cold hands and feet and cold sweat, it is recommended to go to the regular hospital in a timely manner, under the guidance of a professional doctor for standardized treatment.