The difference between Rosuvastatin and Atorvastatin mainly lies in drug specifications, indications, dosage, contraindications, adverse reactions and other aspects. 1. Drug specifications: Rosuvastatin is commonly used in 5mg, 10mg, 20mg specifications; Atorvastatin is commonly used in 10mg, 20mg, 40mg specifications. 2. Indications: Rosuvastatin is suitable for primary hypercholesterolemia or mixed dyslipidemia that cannot be controlled by dietary modification and other non-drug treatments, as well as pure familial hypercholesterolemia; Atorvastatin is also suitable for the above diseases, and it is also used for people with coronary heart disease, diabetes mellitus, etc. who have combined hypercholesterolemia or mixed dyslipidemia. 3. Dosage: The usual starting dose of Rosuvastatin is 5mg/times, once/day, and the maximum dose can be increased to 20mg/times, once/day; the usual starting dose of Atorvastatin is 10mg/times, once/day, and the maximum dose can be increased to 80mg/times, once/day. 4. Contraindications: Rosuvastatin is contraindicated in patients who are allergic to it, pregnant and lactating women, patients with active liver disease, patients with myopathy, etc. Atorvastatin is also contraindicated in patients who are allergic to it, pregnant and lactating women, patients with active liver disease. 5. Adverse reactions: the common adverse reactions of Rosuvastatin are headache, constipation, fatigue, etc.; the adverse reactions of atorvastatin include myalgia, diarrhea and nausea. In summary, the specific use of Rosuvastatin and Atorvastatin must be strictly under the guidance of a doctor, do not blindly use or increase or decrease the dosage of medication, so as not to cause adverse effects.