Treatment of blistering lips takes time and there is no “fastest solution”. Lip blisters may be related to herpes simplex virus infection, hand, foot and mouth disease, bacterial infection, allergy, trauma, nutritional deficiency, etc. Depending on the cause of the disease, it should be resolved through lifestyle modification, medication (applying fusidic acid ointment, etc.), and so on. 1. Herpes simplex virus infection: generally can be cured by itself, if localized infection occurs, it can be treated with medication such as applying fusidic acid ointment. 2. Hand, foot and mouth disease: can use interferon a spray treatment, if the body temperature rises, need to use fever patches or hot water bath to cool down, the body temperature reaches 38.5 degrees or more, need to oral ibuprofen and other drugs to lower the temperature treatment. At the same time, we should pay attention to patient isolation, to avoid the spread of disease. 3. Bacterial infections: patients with bacterial infections are treated with anti-inflammatory drugs such as mupirocin ointment orally, and if the lesions spread to the whole body, cefixime, cefuroxime and other drugs can be taken for treatment. 4. Allergy: allergy patients will be accompanied by itching symptoms, need to avoid scratching, oral cetirizine hydrochloride, diclofenac tadalafil and other drugs. 5. Trauma: If the trauma is caused by the local ice packs, avoid the blisters to squeeze, small blisters can generally be self-absorbed. 6. Nutritional element deficiency: For patients with nutritional element deficiency, it is necessary to supplement calcium, iron, zinc, selenium and other nutrients, such as oral multivitamin tablets, calcium tablets and so on. It is recommended that patients seek medical attention in a timely manner, the first clear cause of the disease, strictly comply with the doctor’s instructions for the appropriate treatment and medication, not unauthorized use of medication.