Chinese medicine believes that waking up from sleep with dry mouth and bitterness is related to physiological factors such as excessive dryness in the sleeping environment and improper diet before going to bed. In addition, it is also considered to be related to liver fire and Shaoyang disease. 1. Physiological factors: excessive dryness of the sleeping environment at night, spicy and stimulating or fatty foods before going to bed, etc., can easily cause dry mouth and bitterness when waking up. 2. Liver fire: mainly related to emotional depression, dietary intemperance and other factors, can cause patients to appear bitter mouth, yellow urine, dizziness, red face and red eyes, eye pain and other symptoms, can also be manifested as waking up with a dry mouth and tongue, bitter. Liver fire can follow the doctor’s instructions with gentian liver pill, Chaihu Shu liver pill and other proprietary Chinese medicines to regulate, but also feasible acupuncture therapy, massage and so on. 3. Shaoyang disease: mostly transformed from sun disease (wind-cold evil attacking the human body’s muscle surface, appearing fear of cold and fever, head and body pain, floating pulse), Shaoyang disease can cause the patient to appear bitter mouth, dry throat, dizziness and other symptoms, can also be manifested as waking up in bed with a dry mouth and tongue, bitterness. Usually, patients can follow the doctor’s instructions to treat with Chinese patent medicines such as Free Pill and Xiao Chaihu Granules, and can also perform other treatments such as acupuncture and acupressure. It is recommended that patients who wake up with dry mouth and bitterness should consult a doctor in time for diagnosis and treatment. Daily attention to the rationality of diet, keep calm, create a good sleep environment.