There are many causes of generalized fatigue and pain, such as insufficient rest, colds and anxiety disorders. 1. Insufficient rest: living late at night for a long time will disrupt the biological clock of the human body, resulting in the brain tissue does not get enough rest time, which will make the brain tissue ischemia and lack of oxygen, the muscles to maintain tension and cause general fatigue, pain and other symptoms. 2. Cold and flu: due to the infection of viruses or bacteria and other pathogens, the pathogens will attack the human body tissues and produce inflammatory substances and metabolites in the human body, resulting in generalized fatigue and pain. 3. Anxiety disorders: severe anxiety disorders can cause autonomic dysfunction and somatosensory disorders, resulting in generalized fatigue and pain. The above are only some of the common causes. If you are suffering from generalized fatigue and pain, you should pay attention to it, go to the hospital in time, and follow the doctor’s instructions for standardized treatment after a clear diagnosis.