Loss of voice due to smoking and coughing may be caused by local edema of the larynx and vocal cords, or it may be caused by tumor due to long-term smoking, and the vocal cord movement disorder caused by the compression of the tumor. 1. Loss of voice due to local edema of the throat and vocal cords: long-term smoking and coughing patients, due to the long-term stimulation of harmful gases in the smoke, can lead to chronic inflammation of the mucosal tissues of the larynx and the vocal cords, under the stimulation of chronic inflammation, the local tissues can undergo edema, congestion and thickening, or atrophy, thinning, drying, and other pathological changes, which will lead to loss of voice. Treatment should quit smoking, avoid spicy and stimulating food, keep the indoor air moist and avoid stimulation of irritating gas. 2. Loss of voice caused by tumor compression: Long-term smoking, due to the carcinogenic substances such as benzopyrene contained in the tar produced by tobacco burning, can lead to laryngeal cancer and lung cancer. When laryngeal cancer occurs, loss of voice can occur due to tumor invasion to the vocal cords; when lung cancer occurs, due to the tumor itself or tumor metastasis to the mediastinal lymph nodes, it can compress the laryngeal recurrent nerve, which can paralyze the vocal cords and lead to loss of voice. For treatment, smoking should be quit, and treatment for laryngeal cancer and lung cancer can be carried out through surgery and radiotherapy, chemotherapy, targeted therapy, etc. Drugs can be chosen such as cisplatin, gemcitabine, methotrexate and erlotinib. In addition to the reasons listed above, loss of voice may also be caused by other reasons, please consult a doctor as soon as possible to avoid delaying the condition.