High glycoantigen 19-9 can be seen in the following three situations: first, it can be seen in normal people, such as smoking, drinking, staying up late, etc. can lead to a transient increase of glycoantigen 199; second, it can be seen in some non-malignant lesions, such as diabetic patients, inflammation of the gallbladder, or stones, renal insufficiency, acute and chronic pancreatitis and cirrhosis, etc. In these benign lesions, glycoantigen 19-9 is often transiently elevated, and the concentration is not too high; thirdly, it is seen in some malignant lesions, mainly tumors of the gastrointestinal tract, such as gallbladder cancer, liver cancer, pancreatic cancer, colon cancer, and gastric cancer, which can be primary tumors or metastatic tumors of the digestive tract.