The side effects of anti-angiogenic drugs are milder than traditional chemotherapeutic drugs, mainly focusing on the cardiovascular system, for example, if the patient had hypertension before, the use of anti-angiogenic drugs may lead to an increase in hypertension. If the patient had heart lesions before using the drug, the use of the drug may lead to aggravation of cardiac symptoms, such as accelerated heart rate and myocardial ischemia. In addition, cases of proteinuria and altered blood supply to the kidneys due to anti-angiogenic drugs have been reported abroad. Considering the difference between the national physique and Westerners, the side effects of domestic drugs will be milder.