Fever after pituitary tumor surgery, this situation must be taken seriously, improve the relevant examination, clear diagnosis, in order to be able to treat from the root. Firstly, the most worrying situation is intracranial infection, if the surgery is transnasal butterfly approach pituitary tumor surgery, this kind of surgery belongs to the relatively contaminated surgery, if the aseptic operation is not paid attention to during the surgery, it is very likely to cause intracranial infection in a retrograde way. Therefore, it is necessary to do lumbar puncture examination to clarify the nature and amount of cerebrospinal fluid and exclude whether it is intracranial infection. The second point is the possibility of central hyperthermia, because when removing the pituitary gland, especially if the pituitary tumor is too large, it affects the hypothalamus, resulting in the possibility of central hyperthermia. It is necessary to improve the examination to exclude other factors of infectious nature, and symptomatic treatment can be carried out. The third point, lung infection, because the pituitary tumor requires general anesthesia surgical treatment. After general anesthesia surgery, many patients have lung infections, and need to do chest CT examination to clarify the basic changes in the condition, and antibiotics can usually be applied. There are other absorbed fever or fever caused by intravascular contamination, which need to be diagnosed after perfect examination and are relatively rare.