There are various reasons for headache after pituitary tumor surgery, and it must be identified accordingly in the clinic: the first one is edema of peripheral nerves and tissues, during surgery, the peripheral nerves and blood vessels will inevitably be damaged, and swelling will occur after surgery, and the released inflammatory mediators will stimulate intracranial nerve tissues and thus produce headache, and it is necessary to actively carry out the treatments of reducing swelling as well as dehydrating and lowering the cranial pressure, and this is the most common but can be effectively prevented through active treatment. This is the most common but can be effectively prevented by active treatment; second, rebleeding, headache, nausea, severe vomiting and even visual impairment after pituitary tumor surgery, head CT must be carried out immediately, it is very likely that the pituitary tumor is rebleeding after surgery, this situation is not uncommon and is the most critical situation must be taken seriously; third, intracranial hematoma, surgery is a very serious process that can be accompanied by any kind of blood loss, but it is not a serious problem. Surgery is a very serious process that can be accompanied by any number of things, and intracranial hematoma may also occur after pituitary tumor surgery, and the persistent lack of significant improvement must be considered as whether an intracranial hematoma has re-formed.