Patients with pediatric anaphylaxis syndrome have persistent cyanosis from birth. Difficulty in breathing. Feeding difficulties. Growth retardation. Tachycardia with signs of hypoxia. It resembles cyanotic congenital heart disease. Spleenless syndrome, also known as Ivemark syndrome, spleenless with congenital heart disease syndrome, splenic insufficiency syndrome, congenital splenic agenesis with atrial and visceral transposition syndrome, etc., is characterized by congenital splenic insufficiency or absence of spleen, with cardiac macrovascular malformation with cavernous and pulmonary venous reflux abnormalities, and combined with abnormal position of thoracoabdominal viscera. So how is persistent cyanosis diagnosed right after birth? Here is an explanation. The diagnosis of persistent cyanosis after birth: 1, persistent cyanosis Patients have persistent cyanosis after birth, breathing difficulties, feeding difficulties, growth retardation, tachycardia and present symptoms of hypoxia, similar to cyanotic congenital heart disease. Signs and symptoms of cardiovascular abnormalities Older patients may have pestle-like fingers (toes), elevated precordial area, and diffuse systolic murmurs along the left border of the sternum in about half of the cases. 3, no spleen Abdominal ultrasound reveals a very small or even absent spleen. 4.Poor immune function, low resistance, frequent infections, serious infections are often the cause of death. 5.Multiple malformations In addition to the absence of spleen and cardiovascular malformations, there are often abnormalities such as gastrointestinal transposition. 6.Blood examination The presence of Howell-Jolly vesicles in peripheral blood erythrocytes is of confirmatory significance.