High thyroid stimulating hormone is commonly found in patients with hypothyroidism or subclinical hypothyroidism, which may not have specific clinical symptoms, or may present with hypothyroidism symptoms such as fatigue, drowsiness, chillsiness, panic, edema, weight gain, etc. Symptoms may be different if the thyroid stimulating hormone is high due to other reasons. Thyrotropin is an important hormone secreted by the pituitary gland, with a normal adult range of 0.35-5.5 μIU/ml. its physiological role is to stimulate the development of thyroid cells, synthesis and secretion of thyroid hormones. Its secretion is promoted by thyrotropin-releasing hormone and inhibited by growth inhibiting hormone, and is subject to negative feedback regulation by thyroid hormone. Elevated thyroid stimulating hormone is commonly seen in primary hypothyroidism, heterogenic thyroid stimulating hormone secretion syndrome, simple goiter, hyperpituitary gland, thyroiditis, etc.; it is also seen in the application of dopamine antagonist, iodine-containing drugs. High thyroid stimulating hormone, if seen in hypothyroidism and other diseases, may appear fatigue, drowsiness, chills, panic, edema, weight gain and other symptoms; if seen in pituitary hyperfunction and other diseases, may appear restlessness, irritability, insomnia and other symptoms; if seen in other factors due to mildly elevated, due to the existence of the body’s self-regulation mechanism, there may be no obvious symptoms. When high thyroid stimulating hormone is detected, it is necessary to consult a doctor in time to find out the cause and have a professional doctor formulate an individualized diagnosis and treatment plan, so as to avoid delaying the condition.