Commonly applied drugs for perioral dermatitis include silicone cream, erythromycin ointment, metronidazole, clindamycin, etc., which need to be selected according to the specific situation. Perioral dermatitis is an inflammatory skin disease that occurs on the upper lip, nasolabial folds, nose and other parts of the body, the specific pathogenesis is not clear, and may be related to long-term topical glucocorticoids, fluoride toothpaste, helminthic mite infections, etc., and you need to choose the drug according to the situation. First of all, you need to stop using all allergic substances or drugs related to perioral dermatitis, such as fluoride toothpaste and hormone drugs. 1. Silicone cream: For perioral dermatitis, you can use hormone-free moisturizers such as silicone cream on the affected area. 2. Erythromycin ointment: Erythromycin ointment is a macrolide antibiotic, patients with perioral dermatitis, you can use erythromycin ointment topical application, can play an anti-inflammatory and anti-infectious effect. 3. Metronidazole: Metronidazole is an anti-anaerobic drug, anti-trichomonas drug, for patients with perioral dermatitis, you can apply metronidazole gel, cream and so on, so as to prevent anaerobic infections. 4. Clindamycin: Clindamycin, also known as clindamycin hydrochloride, is mainly an antibiotic drug that can prevent infections caused by streptococcus, staphylococcus, and anaerobic bacteria and other sensitive organisms, and can be used in conjunction with other antimicrobial drugs according to your own situation if necessary. All of the above medications should be used under the guidance of a doctor, avoid self-medication to avoid adverse effects.