There is generally no quick fix for a late night cough. Late-night cough can be caused by a variety of diseases, commonly found in respiratory diseases such as acute bronchitis, cough variant asthma, digestive diseases such as gastroesophageal reflux disease, etc., need to take a different drug treatment. 1. Acute bronchitis: mainly due to viral or bacterial infections, can cause inflammatory reaction of the bronchial mucosa, resulting in increased secretions, can cause late-night cough. If you have a dry cough, you can take cough suppressants such as dextromethorphan. If there is phlegm that cannot be easily coughed up, it can be treated with expectorants such as cough suppressants. If there is evidence of bacterial infection, antibiotics such as amoxicillin may be used. 2. Cough variant asthma: due to airway hyperresponsiveness, stimulated by factors such as odors and air in the environment, leading to spasm of the bronchial tubes, causing nocturnal paroxysms of coughing, usually taking leukotriene modulators such as montelukast or inhaled glucocorticosteroids such as budesonide powdered inhaler. 3. Gastroesophageal reflux disease (GERD): mainly occurs after meals or when lying down, gastric juices will reflux into the throat and trachea, causing coughing symptoms. You can take acid-suppressing drugs such as omeprazole, gastrointestinal stimulants such as domperidone, and surgery to relieve symptoms in severe cases. There are many reasons for late-night coughing, and once a patient experiences persistent late-night coughing symptoms, he or she should go to the hospital for a timely examination, and follow the doctor’s instructions according to the results of the examination, so as to avoid delaying his or her condition.