The two of them finally got married with their girlfriend. The couple finally couldn’t resist going to the hospital for a checkup, and the test results made them run into tears. The results were no less than a bolt from the blue, and they couldn’t accept the reality for a long time. The company has been very confused: “We are quite satisfied with our sex life, and we have ejaculated every time, so how can there be no sperm?” The fact is that the main component of semen is the secretion of the seminal vesicles and prostate gland, while the proportion of sperm produced by the testicles is less than 5%, only through the microscope to identify the presence of sperm in the semen, azoospermia patients ejaculated semen is like “rice porridge”. The semen ejaculated by azoospermia patients is like “porridge without rice”, slightly thin, but the process of sexual life itself is not affected. Azoospermia and sexual performance are not necessarily related, except in a few cases of severe endocrine abnormalities. How to diagnose azoospermia and what are the specific causes The amount of semen in each ejaculation is about 2-6 ml, but for sperm, it is like a vast ocean. In order to avoid a small amount of sperm not being found in the semen, it is recommended that routine semen examination be performed at least three times and the semen be centrifuged and tested again, but no sperm is found before azoospermia is diagnosed. The causes of azoospermia include blockage of the vas deferens, chromosomal abnormalities, cryptorchidism, testicular dysplasia, mumps or other causes of orchitis, tumor chemotherapy damage, and endocrine hypofunction. Among them, the treatment is relatively simple for azoospermia caused by dysplasia or blockage of the vas deferens, which can be treated by “fine needle aspiration” to extract the active sperm from the testes or epididymis, and then produce their own offspring through “in vitro fertilization”. Microscopic sperm retrieval, even the smallest testicles have the hope of finding sperm For chromosomal abnormalities (the most common is an extra chromosome, 47 XXY), severe testicular dysplasia, testicular inflammatory atrophy and other causes of testicular spermatogenesis failure, azoospermia, there is a lack of effective treatment methods, many hospitals will advise those with small testicles, high blood test indicators (high follicle stimulating hormone FSH), 47 XXY This is because traditional biopsy methods, whether incisional biopsy or fine needle aspiration, are very difficult to find sperm for these patients with severe spermatogenic disorders. However, with the pioneering of “microscopic sperm extraction” and its accumulated technical improvements, the success rate of testicular sperm retrieval has increased significantly and the barriers of reproductive technology are gradually being broken through, rekindling the hopes of many helpless patients. Studies have shown that even in patients with severely low spermatogenic function, some viable spermatogenic tissues may still remain in the testes, but because these tissues are so rare, it is difficult to find them by traditional biopsy methods. The probability of finding these tissues increases by about 35% after 15-20 times magnification with the aid of a surgical microscope, just as it is possible to find an oasis in the desert. According to current experience, small testes, significantly elevated FSH, or even abnormal 47 XXY chromosomes do not decrease the probability of finding sperm, and the probability of finding sperm in a testicle as small as 2 ml (about the size of a peanut meter) is the same as in a testicle of normal size, and the probability of finding sperm in a testicle with 47 XXY of Creutzfeldt-Jakob sign is about 50%. Microscopic sperm retrieval has been performed in the Department of Gynecology of the Sixth Hospital of Sun Yat-sen University and has helped some (50%) of the azoospermia patients who previously lost their chance of treatment to successfully have their own babies.