Although there is not much evidence on the relationship between fertility and antiviral treatment in male patients with hepatitis B, the situation is much simpler than that of women. 1, for the treatment of planned conception, antiviral drugs can be given first, waiting for a sustained response to treatment, and then conceiving after a period of drug withdrawal; or conception can be carried out before antiviral treatment, followed by antiviral treatment. 2, for patients who are receiving antiviral therapy to plan for conception, interferon drugs must be discontinued for more than 3 months before conception; nucleoside drug treatment, for milder cases can be discontinued for 3 weeks before conception, and for more serious cases can not stop the drug can be replaced with lamivudine, tenofovir or telbivudine treatment for a period of time before conception. 3, for men taking oral nucleoside drugs during the accidental pregnancy, after fully informed communication, the woman can continue the pregnancy, but need to be closely observed; for men applying interferon treatment during the accidental pregnancy, because of its safety is unknown, after fully informed communication, it is recommended that the woman genetic eugenics counseling before deciding whether to continue the pregnancy.