Low transaminases are normal and not diagnostic of disease, but if they are elevated, it is important to be aware of liver and gallbladder disease. Transaminases are found mainly in the liver cells and are particularly low in the peripheral blood, where they cannot even be detected. If the aminotransferases are found to be low, it means that there is no aminotransferases in the blood and that the patient is healthy. The main purpose of the transaminase test is to determine whether the transaminase is elevated. Once liver cell damage occurs, the transaminase level in the peripheral blood will increase, and the greater the damage to the liver cells, the higher the transaminase level will rise. For people with elevated aminotransferases, further liver and gallbladder function tests should be conducted to help confirm the diagnosis of the disease. Common diseases that can lead to elevated aminotransferases include cirrhosis, fatty liver, viral hepatitis, cholecystitis, and gallbladder stones.