Adverse effects such as fever, redness and swelling at the injection site are often seen after injection of 13-valent pneumonia vaccine. However, the symptoms of such adverse reactions are relatively mild and can be recovered after 48-72 hours. Since the principle of most vaccines is to inactivate bacteria and viral toxins and then inject them into the body, a series of adverse reactions may occur during the process of antibody production. In some cases, the adverse reactions may be more pronounced and last for a longer period of time due to poor physical condition. However, if there is recurrent fever for more than 3 days, it may be caused by other reasons, it is still recommended to go to the hospital in a timely manner, to clarify the cause of the fever, and symptomatic treatment.