Pain in liver disease is mainly characterized by pain in the right upper abdomen, also known as the liver area. It is mostly seen in patients with chronic viral hepatitis, or alcoholic cirrhosis caused by year-round alcohol consumption. After exertion, the patient will also show weakness, discomfort, distension and pain in the right upper abdomen, and after overeating or eating greasy and spicy food, it will also lead to the onset of pain, and it can even radiate to the back of the right shoulder, and there is obvious percussion pain in the area of the quarter ribs. If the liver is enlarged and there is obvious tenderness in the liver region, systematic treatment is needed, and at the same time, stimulating foods should be kept away from. Regular review of liver function is needed, as it is usually combined with abnormalities of aminotransferases or bilirubin, and in severe cases, intravenous liver-protecting therapy is needed.