Knee pain at night can be treated by daily care, medication and surgery, but since there are many causes of knee pain at night, such as cold, muscle injury, osteoarthritis, etc., the specific treatment needs to be chosen according to the cause. 1. Cold: If you sleep with less blanket, your knees will get cold and cause knee pain. Should promptly improve the sleeping environment, timely replacement of blankets, avoid prolonged exposure to air-conditioned rooms, to reduce the stimulation of the patient, after a period of time can be recovered on their own. 2. Muscle injury: should reduce exercise, pay attention to rest, you can use a water bag and hot towels on the affected area for hot compresses, promote blood circulation, then in serious cases, you can choose to use ibuprofen extended-release capsules, diclofenac sodium extended-release tablets and other drugs to relieve pain, but also the use of fluorozolazone tablets, ethylphenidate hydrochloride tablets, and other muscle relaxation drugs for treatment. 3. Osteoarthritis: should be braked to rest, avoid weight-bearing exercise, you can choose to use indomethacin enteric-coated tablets, ibuprofen extended-release capsules, as well as glucosamine hydrochloride tablets, glucosamine sulfate tablets and other nutritious cartilage medication for treatment, the serious cases need to be timely arthroscopic surgery for treatment. It is recommended to go to the hospital for examination and diagnosis in a timely manner, to clarify the cause of the disease, and to carry out targeted treatment and take medication under the guidance of professional physicians, which will be conducive to the recovery of the condition.