Low-grade squamous intraepithelial lesions have a low chance of becoming cancerous, and about 60% of patients can regress on their own, so they can be observed and followed up only without special treatment. Squamous intraepithelial lesions of the uterine cervix include high-grade and low-grade squamous intraepithelial lesions, which are a group of cervical lesions closely related to cervical cancer. Low-grade squamous intraepithelial lesions have a better prognosis and are less likely to become cancerous, with about 60% of them resolving on their own. Low-grade squamous intraepithelial lesions are usually asymptomatic and may occasionally present with increased vaginal discharge. Screening tools include cervical cytology, human papillomavirus testing, colposcopy testing and tissue biopsy. Those with low-grade squamous intraepithelial lesions on cytologic examination can be followed up for observation only; if the disease progresses during observation, treatment should be provided, and those with low-grade squamous intraepithelial lesions can be treated with cryotherapy and laser therapy after adequate examination. Regular medical checkups can help in the early detection of the disease, if conditions permit.